ea0016p308 | Endocrine tumours | ECE2008
Ronchi Cristina L
, Sbiera Silviu
, Adams Patrick
, Kraus Luthgard
, Linss Heidi
, Wortmann Sebastian
, Willenberg Holger
, Allolio Bruno
, Fassnacth Martin
Adrenocortical carcinoma (ACC) is a malignant tumor with poor prognosis and no established therapy in advanced stage. Cisplatin is the most frequently used cytotoxic drug, but even combined with doxorubicin and etoposid, the response rate is <50%. Recently, it has been demonstrated that the excision repair cross complementing group 1 (ERCC1) plays a relevant role in the DNA repairing process, particularly in the correction of platinum-induced DNA adducts. Accordingly, ERCC...